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The mutagenic capacity of tretinoin was reviewed in the ames assay and in the in vivo mouse micronucleus assay, both of which were bad.

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Less serious side effects may include burningwarmthstingingtinglingitchingrednessswellingdrynesspeelingirritationor discolored skin.

Alterations of vehicledrug concentrationor dose frequency should be closely monitored by careful observation of the clinical therapeutic response and skin tolerance.

If you have recently used products containing sulfurresorcinol or salicylic aciduse tretinoin with cautionWait until the effects of such products on the skin have decreased before using tretinoin.

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