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In some casesa patient already receiving SARAFEM therapy may require urgent treatment with linezolid or intravenous methylene blueIf acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin syndrome in a particular patientSARAFEM should be stopped promptlyand linezolid or intravenous methylene blue can be administeredThe patient should be monitored for symptoms of serotonin syndrome for five weeks or until 24 hours after the last dose of linezolid or intravenous methylene bluewhichever comes firstTherapy with SARAFEM may be resumed 24 hours after the last dose of linezolid or intravenous methylene bluesee WARNINGS AND PRECAUTIONS

Patients should be cautioned about the risk of bleeding associated with the concomitant use of fluoxetine and NSAIDsaspirinwarfarinor other drugs that affect coagulationsee DRUG INTERACTIONS

Pulmonary reactionsincluding inflammatory processes of varying histopathology and/or fibrosishave been reported rarelyThese reactions have occurred with dyspnea as the only preceding symptom.

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