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For the prevention of seasonal major depressive episodes associated with seasonal affective disorder, bupropion hydrochloride extended-release tablets xl should generally be initiated in the autumn prior to the onset of depressive symptoms.

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Swallow the sustained-release and extended-release tablets wholedo not splitchewor crush them.

Smoking cessation may also cause new or worsening mental health problemssuch as depression.

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Observe for neuropsychiatric symptomssuch as changes in behaviorhostilityagitationdepressed moodand suicide-related eventsincluding ideationbehaviorand attempted suicidetherapy may cause delusionshallucinationspsychosisparanoiaconfusionand concentration disturbancesymptoms may abate with dose reduction.

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when subjects in this trial were followed out to 1 year, the superiority of bupropion and the combination of bupropion and nts over placebo in helping them to achieve abstinence from smoking was maintained.

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